THE DIFFERENT TIMING OF ORAL CLONIDINE PREMEDICATION EFFECT ON SEDATION SCORE IN SPINE SURGERY

Abstract

Background: Premedication is the administration of medication before anaesthesia. It is used to prepare the patient for anaesthesia and to provideoptimal conditions for surgery.

Methods: The study of oral premedication dose of clonidine in spinal surgery at different time was conducted on sixty ASA grade-1 patients of eithersex between 20 to 60 years of age undergoing elective spine surgery. This study was performed after approval from ethics committee of the institute.Informed consent was obtained from each patient.

Results: The total induction dose of propofol required for the induction of the patient is 2-2.5 mg/kg body weight. In our study the average weightof the patient in group-1 was 58.83 kg and in group-2, average weight of the patient was 54.77 kg. The total average weight of patient in the study was 56.80 kg. Thus the total induction dose of propofol required should have been 117.66 mg in group-1, 109.54 mg in group-2 and 113.6 mg in averagetotal.

Conclusion: In conclusion this study establishes that the premedication with tab. clonidine 200µg (As tab. clonidine is available in 100µg) 90 minutebefore the surgery or 3.5 hour before the surgery reduced induction dose of propofol.

Keywords: Clonidine, Propofol, Spine