https://www.ijmbs.info/index.php/ijmbs/issue/feed International Journal of Medical and Biomedical Studies 2022-01-18T09:22:48-05:00 IJMBS editor@ijmbs.info Open Journal Systems <p><strong>Aims and Scope</strong></p> <p>International Journal of Medical and Biomedical Studies&nbsp;(IJMBS) is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Medical and Biomedical Studies.</p> <p>International Journal of Medical and Biomedical Studies&nbsp;is an academic journal which aims to publish complete and reliable source of information in the field of medical research providing the fundamental knowledge for further research.&nbsp;<em>IJMBS</em>&nbsp;commits to publish the results of researches in medical practice, risk factors and preventive medicine, safety and effectiveness of treatments, and diagnostic tools that are used to treat any disease. 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Hepatic involvement can be characterized by manifestations of acute hepatitis, with pain in the right hypochondrium, hepatomegaly, jaundice, and raised aminotransferase levels. Although the liver is not the directly targeted organ for dengue virus, histopathological findings, including centrilobular necrosis, fatty alterations, hyperplasia of the Kupffer cells, acidophil bodies and monocyte infiltration of the portal tract have been detected in patients with dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). In most cases, hepatic involvement prolongs the clinical course of this self-limiting viral infection, but it does not constitute a sign of worse prognosis.</p> <p><strong>Methods:</strong> Hundred confirmed diagnosed inpatient cases of dengue fever were included. Clinical examination and laboratory investigations including liver function tests and serum electrolyte levels were performed regularly at appropriate interval. Viral hepatitis testing was also performed to check for any co-infection or pre-existing viral hepatitis. On the basis of increase in serum aminotransferase levels, patients were divided into two groups; Mild (up to 5 times normal) to Moderate (5- 10 times) acute hepatitis: AST or ALT 45-300 IU/L and severe acute hepatitis: AST or ALT &gt; 300 IU/L or ? 10 times. On basis of serum protein levels, the patients were grouped in two groups, one with hypoalbuminemia; serum albumin &lt;3.0 g/dL and without hypoalbuminemia</p> <p><strong>Results</strong>: In this study out of total 100 patients 67 were men (67%) and 33 were women (33%). The mean age of the patients was 39 ± 3.1 years. The patients were in the range of age 22-54 years. Maximum number of patients were in third decade of life.&nbsp; All the patients were tested positive for NS1 antigen test. Fever was the most common presenting complaint with mean duration of fever was 6 ± 3.27 days with mean temperature of 38.5 ± 1°C, 21% had abdominal pain, 17% had rash, 3% had jaundice. Liver function tests (LFTs) show the median ALT of 88.50 IU/L with range from 43.25-317.22 IU/L, median AST of 174 IU/L with range from 47-371.5 IU/L. 91% of the patients had elevated AST levels and almost 79% patients had elevated ALT (hepatitis). Normal levels of serum aminotransferase AST and ALT levels were seen in 9% and 21% patients respectively. Mild to moderate increase in AST and ALT levels were seen in 84% and 75% of cases respectively whereas more than 10-fold increase in AST and ALT levels were seen in 7% and 4% patients respectively as shown in Table 1. Mortality was 2% in our study.</p> <p><strong>Conclusions: </strong>Dengue viral fever contributes significantly to the disease burden in developing countries. Although the disease is self-limiting, but a significant number of cases show signs of organ dysfunction including liver dysfunction. The diagnosis of Dengue may be difficult in some cases due to false negative reports in first few days. It is thus important to investigate all suspected dengue patients with liver function test (serum transaminases levels), so that liver dysfunction can be detected early and proper management can be initiated.</p> <p><strong>Keywords: </strong>Dengue Viral Fever, Immune Hepatitis, Serum Aminotransferases, Hepatic Dysfunction.</p> 2022-01-18T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2395 STUDY OF OUTCOME OF STATIN THERAPY IN PATIENTS BY CHECKING LIPID PROFILE AFTER 3 MONTHS OF STARTING TREATMENT IN STATIN NAIVE PATIENTS 2022-01-16T02:06:34-05:00 Shilpa Atwal EDITOR@IJMBS.INFO Jitender Thakur EDITOR@IJMBS.INFO <p><strong>Background:</strong> To describe the outcome of statin therapy in patients by checking lipid profile after 3 months of starting treatment in statin naive patients</p> <p><strong>Methods:</strong> Study was conducted on Patients with indications for statins presenting to cardiology OPD, Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months.</p> <p><strong>Results:</strong> The mean decrease in total cholesterol, triglycerides, VLDL and LDL levels in primary prevention group mean decrease in after 3 months of statin treatment in comparison to baseline were 17.24%,21.24%, 22.83 % and 33.19% respectively and increase in mean HDL level was 9.55%. The mean decrease in total cholesterol, triglyceride, VLDL and LDL levels in secondary prevention group after 3 months of statin treatment in comparison to baseline were 14.35% 15.80%, 16.17% and 36.92% respectively and increase in mean HDL level was 8.77%.</p> <p><strong>Concluded:</strong> So there was statistically significant change in lipid profile from baseline in both primary and secondary prevention groups after 3 months of statin treatment.</p> <p><strong>Keywords:</strong> Statin, LDL,VLDL, HDL</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2393 PATTERNS OF PRESCRIPTION OF STATINS IN A TERTIARY CARE CENTRE OF NORTH INDIA 2022-01-16T01:50:04-05:00 Shilpa Atwal EDITOR@IJMBS.INFO Jitender Thakur EDITOR@IJMBS.INFO <p><strong>Background:</strong> To study the pattern of prescription of statins in a tertiary care centre.</p> <p><strong>Methods:</strong> Study was conducted on Patients with indications for statins presenting to cardiology OPD, Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months.</p> <p><strong>Results:</strong> Atorvastatin was found to be more commonly prescribed (n=179), which is about73.7%compared to Rosuvastatin (n=64) which is about 26.3%. In our study, 75 (68.8%)patients of primary prevention group and 104(77.6%) patients of secondary prevention group were receiving Atorvastatin and 34 (31.2%) patients of primary prevention group and 30(22.4%)patients of secondary prevention were receiving Rosuvastatin on their prescription.</p> <p><strong>Concluded:</strong> In our study, there were prescriptions with only Atorvastatin and Rosuvastatin. No prescription with other statins was found. Atorvastatin was being more commonly prescribed to rosuvastatin.</p> <p><strong>Keywords:</strong> Statin, Atorvastatin, Rosuvastatin</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2391 TO EVALUATE EFFICACY OF LAPAROSCOPIC TRANSPERITONEAL PYELOLITHOTOMY FOR MANAGEMENT OF RENAL PELVIC STONES IN TERM OF BLOOD LOSS 2022-01-16T01:31:32-05:00 Bharat Thakur EDITOR@IJMBS.INFO Ankit Panwar EDITOR@IJMBS.INFO Shivek Mohan EDITOR@IJMBS.INFO Ved Kumar Sharma EDITOR@IJMBS.INFO <p><strong>Background:</strong> To evaluate efficacy of laparoscopic transperitoneal pyelolithotomy for management of renal pelvic stones in term of blood loss</p> <p><strong>Methods:</strong> This study has been conducted in the Department of General surgery, Indira Gandhi Medical College, Shimla on selected patients of Renal pelvis stones admitted in institution</p> <p><strong>Results:</strong> Mean blood loss in successful laparoscopic surgery was 58.33 ml and in lap converted to open was 200 ml.</p> <p><strong>Conclusion:</strong> Laparoscopic pyelolithotomy is a feasible and safe operation for patients with renal stones in centers with adequate experience in laparoscopy and well trained surgeons. It is found to be safe, effective and efficient with proper patient selection and adherence to standard laparoscopic surgical principles.</p> <p><strong>Keywords:</strong> Laparoscopic Transperitoneal Pyelolithotomy, Pelvic stone, Blood loss</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2389 TO EVALUATE EFFICACY OF LAPAROSCOPIC TRANSPERITONEAL PYELOLITHOTOMY FOR MANAGEMENT OF RENAL PELVIC STONES IN TERM OF POSTOPERATIVE HOSPITAL STAY 2022-01-16T01:11:32-05:00 Shivek Mohan editor@ijmbs.info Ankit Panwar editor@ijmbs.info Bharat Thakur editor@ijmbs.info Ved Kumar Sharma editor@ijmbs.info <p><strong>Background: </strong>To evaluate efficacy of laparoscopic transperitoneal pyelolithotomy for management of renal pelvic stones in term of postoperative hospital stay</p> <p><strong>Methods: </strong>This study has been conducted in the Department of General surgery, Indira Gandhi Medical College, Shimla on selected patients of Renal pelvis stones admitted in institution</p> <p><strong>Results: </strong>Mean hospital stay was 6.66 days in laparoscopic group and it was 8 days in laparoscopic completed by open method. Maximum no. of patients was discharged within 5 days.&nbsp; 6 (75 %) patients returned to normal activity in less than 30 days which included only successful laparoscopic group and 2 patients returned to normal activity in 40 days which included lap completed by open group.</p> <p><strong>Conclusion: </strong>In the present study of Laparoscopic Transperitoneal Pyelolithotomy at Indira Gandhi Medical College, Shimla, the procedure showed a definite decrease hospital stay, early return to activity than who have undergone open surgery</p> <p><strong>Keywords: </strong>Laparoscopic Transperitoneal Pyelolithotomy, Pelvic stone, Hospital stay.</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2383 EFFICACY OF PHOTODYNAMIC THERAPY AS AN ADJUNCT TO NON – SURGICAL PERIODONTAL THERAPY IN TYPE-2 DIABETES MELLITUS PATIENT 2022-01-07T08:44:29-05:00 Roshni Ghosh editor@ijmbs.info Pradeep Shukla editor@ijmbs.info Gaurav Malhotra editor@ijmbs.info Prerna Kataria editor@ijmbs.info Preeti Shukla editor@ijmbs.info Mona Dagar editor@ijmbs.info <p><strong>Background:</strong> To Evaluate the additional benefit of Antimicrobial Photodynamic therapy, if any in the glycemic control of type 2 diabetes mellitus&nbsp; chronic periodontitis patients .</p> <p><strong>Methods:</strong>&nbsp; Fifty&nbsp; diabetic patients with chronic periodontitis were taken for the study who met the inclusion criteria of clinical attachment loss ?3 to 5 mm at ? 30% of sites and bleeding on probing present in two different quadrants . After SRP ( Scaling and root planing ) , one quadrant was selected for aPDT while other served as a control group. Clinical parameters i.e. Plaque index, Probing depth ,Relative attachment level and HBA1c were measured at baseline, 1 week , 1month and 3 months.</p> <p><strong>Results:</strong> Statistically significant differences in the mean probing depth, Relative attachment level, plaque deposit, and HBA1c were found between baseline and 12 weeks post-treatment for both groups. No significant differences in glucose levels were detected among the two&nbsp; groups in 1 week . Reduction in the mean HbA1c level after treatment was observed in both groups in 1 month and 3 months .</p> <p><strong>Conclusion</strong>: &nbsp;Antimicrobial Photodynamic Therapy when used in addition to scaling and root planing yields significant improvement of &nbsp;mean probing depth , Plaque deposit ,Relative attachment levels, &nbsp;periodontal status and reduction of HbA1c levels in treatment of diabetic patients with periodontitis when comparing the test group to the control group.</p> <p><strong>Keywords: </strong>photodynamic therapy , scaling and root planing, glycated haemoglobin ,Randomized controlled trial</p> 2022-01-07T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2373 PROTEIN C AND PROTEIN S ABNORMALITIES IN PATIENTS WITH PLACENTAL ABRUPTION AND ITS ASSOCIATION WITH ADVERSE FETO-MATERNAL OUTCOME 2022-01-03T01:44:54-05:00 Shivangi editor@ijmbs.info Harsha S Gaikwad editor@ijmbs.info <p>Placental abruption is an important cause of maternal and fetal morbidity and mortality. Inherited thrombophilia, which includes Protein C and Protein S deficiency, is an important risk factor for abruption.</p> <p><strong>Objective: </strong>To find the prevalence of Protein C and Protein S abnormalities in patients with placental abruption and its association with adverse feto-maternal outcome.</p> <p><strong>Methods: </strong>A prospective observational study conducted in a tertiary hospital India from 2018 to 2020 for a period of 18 months. All pregnant women with abruption (n=254) were recruited. Peripheral blood samples of patients were collected in 3.2% sodium citrate vacutainers. All these coagulation investigations were performed on compact ceveron Alpha Automated Coagulation Analyzer(Compact bio-sciences Ltd),based on clotting, chromogenic and turbidimetric analysis. Adverse feto-maternal outcome was assessed by finding out the proportion of Prematurity, small for gestation age(SGA), Neonatal intensive care (NICU) admissions, Intra Uterine Death (IUD), number of maternal death, vaginal deliveries, caesarean section, blood transfusion</p> <p><strong>Result: </strong>222 out of 254 cases had protein C in the normal range i.e 67-135 (87.40%). 1 patient had (0.39%) had protein C deficiency and rest 12.20% had protein C level greater than normal range. Out of 254 subjects no case had protein S deficiency. About 43.70% had normal protein S value(33-101).56.30% subjects had value greater than normal range .Range was between 53-148 and mean value was&nbsp; 103 ± 16.51.</p> <p>Adverse fetal outcome was assessed in the patients having abnormal protein C and protein S values, here, mainly those having values greater than the normal range.</p> <p>In our study 1.40% had NND, 6.99% had IUD, 8.39% had perinatal mortality, 39.16% had blood transfusion,26.57 % had LSCS, 40.56%&nbsp; had SGA, 29.32% NICU admission in subjects with abnormal protein S value. For those with normal protein S value 4.50% had NND, 6.31% had IUD, 10.81% had perinatal mortality, 39.64% had blood transfusion, 39.64 % had LSCS, 40.56% had SGA , 29.81% had NICU admission.</p> <p>&nbsp;3.13% of those with abnormal protein C had IUD, 6.25% had perinatal mortality,3.13% had NND,34.38% had blood transfusion,43.75% had SGA babies,22.58%&nbsp; had NICU admission,25 % had LSCS. For those with normal values, 2.70% had NND, 7.21% had IUD, 9.91% had perinatal mortality, 40.09 % had blood transfusion, 40.54% had SGA, 30.58% had NICU admission,33.33 % had LSCS.</p> <p><strong>Conclusion: </strong>Protein C and Protein S deficiency was not found in our patients with abruption rather the values were greater than the normal range. No significant adverse feto-maternal outcome was found in patients with values of Protein C and Protein S greater than normal.</p> <p><strong>Keywords:</strong> NICU, IUD, LSCS, SGA</p> 2022-01-03T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2371 MINIMALLY INVASIVE MITRAL VALVE REPLACEMENT (MIMVR) THROUGH RIGHT MINITHORACOTOMY: A SINGLE-CENTER EXPERIENCE FROM CENTRAL INDIA 2022-01-02T02:02:30-05:00 Piyush Gupta editor@ijmbs.info Manish Porwal editor@ijmbs.info <p><strong>Background:</strong> Minimally invasive mitral valve replacement surgery (MIMVR) is gaining popularity for its multifold advantages. Here we report our single-institution experience with MIMVR through the right minithoracotomy over two years.</p> <p><strong>Materials and Methods:</strong> This study was a retrospective analytical study. Forty-two patients undergoing MIMVR between August 2019 and July 2021 were included. Recorded perioperative data were collected and evaluated retrospectively.</p> <p><strong>Results:</strong> A total of 42 patients were included in the study, of which 29 were females (69%). The mean age was 43.2+/- 8.2 years. Overall 30-day mortality was 2.38% (n = 1). Mean operating time, cardiopulmonary bypass, and aortic cross-clamp times were 264.9 ± 48.7, 151.5 ± 39.8, and 89.8 ± 25.6 minutes, respectively. Tricuspid valve annuloplasty was performed in 8 patients (19%). One patient (2.38%) required conversion to median sternotomy, and three patients (7.1%) underwent re-explorations due to bleeding. The median postoperative hospital stay was 5 days.</p> <p><strong>Conclusions:</strong> MIMVR through right minithoracotomy is feasible, safe, and reproducible with low mortality and morbidity. Mitral valve surgery through a small anterior thoracotomy is a good alternative to conventional thoracotomy.</p> <p><strong>Keywords:&nbsp;</strong>minimally invasive, minithoracotomy, mitral valve replacement</p> 2022-01-02T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2396 STUDY REGARDING ETHICAL VERSUS GENERIC PRESCRIPTION OF STATINS 2022-01-16T02:11:48-05:00 Shilpa Atwal EDITOR@IJMBS.INFO Jitender Thakur EDITOR@IJMBS.INFO <p><strong>Background:</strong> To study the ethical versus generic prescription of statins</p> <p><strong>Methods:</strong> Study was conducted on Patients with indications for statins presenting to cardiology OPD,Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months.</p> <p><strong>Results:</strong> In our study population, amongst the primary prevention group, a larger percentage about 56% were receiving generic prescription of statins and about 44% were receiving ethical prescription of statins .Whereas in secondary prevention group, about 45.5% of patients were receiving generic prescription and 54.5% were receiving ethical prescription .</p> <p><strong>Concluded:</strong> In our study population patients were equally prescribed on ethical (49.8%) and generic prescriptions (50.2%).</p> <p><strong>Keywords:</strong> Statin, Ethical, Generic</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2394 TO STUDY THE USE OF GUIDELINES IN STATINS PRESCRIPTION AT TERTIARY CARE CENTRE OF NORTH INDIA 2022-01-16T01:58:35-05:00 Shilpa Atwal EDITOR@IJMBS.INFO Jitender Thakur EDITOR@IJMBS.INFO <p><strong>Background:</strong> To study the use of guidelines in statins prescription at tertiary care centre of North India</p> <p><strong>Methods:</strong> Study was conducted on Patients with indications for statins presenting to cardiology OPD,Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months.</p> <p><strong>Results:</strong> In our study, 81.9% of total study population were receiving statins according to guideline and 18.1% were receiving statins not according to guideline. In the primary prevention group,91(83.5%) patients were receiving statins according to guideline and 18(16.5%) were receiving not according to guideline. In the secondary prevention group, 108(80.6%) patients were receiving statins according to guideline and 26(19.4%) patients were receiving statins not according to guideline.</p> <p><strong>Concluded:</strong> In our study, more than two third of patients in our study were receiving prescriptions according to guideline</p> <p><strong>Keywords:</strong> Statin, Guideline, Use</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2392 INDICATIONS OF PRESCRIPTION OF STATINS IN TERTIARY CARE CENTRE OF NORTH INDIA 2022-01-16T01:41:49-05:00 Shilpa Atwal EDITOR@IJMBS.INFO Jitender Thakur EDITOR@IJMBS.INFO <p><strong>Background:</strong> To determine the indications for which statins are being prescribed</p> <p><strong>Methods:</strong> Study was conducted on Patients with indications for statins presenting to cardiology OPD,Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months.</p> <p><strong>Results:</strong> In our study, out of 243 prescriptions, 55.1%(n=134) were prescribed statins for secondary prevention and 44.9%(n=109) had statins prescribed for primary prevention. Overall coronary artery disease (37.03%) was the leading indication followed by Diabetes mellitus without ASCVD(70.64%).Other indications of secondary preventionincluded newly diagnosed statin naïve patients diagnosed with stable coronary artery disease ,unstable coronary artery disease /acute coronary artery disease , ischemic cardiovascular accidentsand peripheral arterial disease .64.22 percent patients in primary prevention group were diabetics in our study .</p> <p><strong>Concluded:</strong> We concluded that secondary prevention was found to the more common indication of statin prescription than primary prevention (ratio 1.22:1).</p> <p><strong>Keywords:</strong> Statin, CAD, Prevention</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2390 TO EVALUATE COMPLICATION OF LAPAROSCOPIC TRANSPERITONEAL PYELOLITHOTOMY FOR MANAGEMENT OF RENAL PELVIC STONES 2022-01-16T01:23:49-05:00 Bharat Thakur editor@ijmbs.info Ankit Panwar editor@ijmbs.info Shivek Mohan editor@ijmbs.info Ved Kumar Sharma editor@ijmbs.info <p><strong>Background</strong>: To evaluate complication of laparoscopic transperitoneal pyelolithotomy for management of renal pelvic stones</p> <p><strong>Methods</strong>: This study has been conducted in the Department of General surgery, Indira Gandhi Medical College, Shimla on selected patients of Renal pelvis stones admitted in institution</p> <p><strong>Results</strong>: There were no major postoperative complications. Two patient developed mild low grade fever which subsided on oral antipyretic medication. One patient had a cough and one patient had ileus.</p> <p><strong>Conclusion</strong>: We concluded that there were no major intraoperative or postoperative complications were seen in our study.</p> <p><strong>Keywords</strong>: Laparoscopic Transperitoneal Pyelolithotomy, Pelvic stone, Complication</p> 2022-01-16T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2387 COMPARATIVE STUDY OF PLATELET COUNT IN DIABETIC AND NON-DIABETIC GERIATRIC POPULATION 2022-01-11T23:45:18-05:00 Ayachit Kesharwani editor@ijmbs.info Imran Khan editor@ijmbs.info Mohit Awasthi editor@ijmbs.info Ravija Prasad editor@ijmbs.info <p>Geriatric population (&gt; 60 years) is rapidly increasing in India, It has been increased upto 8.6% in 2011. Diabetes Mellitus (DM) is a metabolic disorder and a major health problem, a?ecting a large section of the Indian population, especially as its incidence increases with advancing age. Host of complications are associated with this disease, one of which is the e?ect on platelet count.&nbsp; This study compares platelet count between diabetic and non-diabetic elderly.&nbsp; It is observed that Hyperglycaemia in diabetic persons is responsible for increased Thrombopoietin production at the cellular level, which leads to raised platelet count -Reticulated Thrombocytosis – when compared to non diabetics. Platelets, especiallyreticulated thrombocytes are associated with uncontrolled blood sugar levels in the body and are well known for their role in artherosclerotic cardiovascular disease (CVD).</p> <p><strong>Keywords:</strong> platelet count, diabetic and non-diabetic &amp; geriatric.</p> 2022-01-11T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2374 TO ASSESS THE INCIDENCE OF DVT AMONG PATIENTS OF LOWER LIMB SURGERIES /LOWER LIMB TRAUMA ADMITTED TO ST. STEPHEN?S HOSPITAL 2022-01-03T01:58:38-05:00 Ankur Rai editor@ijmbs.info Shailendra Kumar Singh editor@ijmbs.info Rajendra Kumar Gupta editor@ijmbs.info <p><strong>Background:</strong> This study therefore aimed to assess the incidence of DVT among patients of lower limb surgeries /lower limb trauma admitted to St. Stephen?s hospital</p> <p><strong>Methods:</strong> The prospective study was conducted at St Stephen?s hospital from Jan 2019 to December 2019 for duration of 1 year, and 104 patients were part of the study.</p> <p><strong>Results:</strong> The overall prevalence of DVT in our study was found to be 2.8%. Out of 3 DVT cases 2 were found in males (3.4%) and 1 was a female (2.1%).</p> <p><strong>Conclusion:</strong> There is comparable incidence of DVT in our patients as compared to the incidence found in world literature. There is a need to institute DVT prophylaxis in patients undergoing major lower limb surgeries.</p> <p><strong>Keywords:</strong> DVT, Lower limb, Trauma</p> 2022-01-03T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies https://www.ijmbs.info/index.php/ijmbs/article/view/2372 COMPARISON OF TRANS-RIGHT ATRIAL VERSUS COMBINED (TRANS-RIGHT ATRIAL, TRANS-RIGHT VENTRICULAR) APPROACH FOR INTRA-CARDIAC REPAIR OF TETRALOGY OF FALLOT: SINGLE-CENTER EXPERIENCE 2022-01-02T02:31:23-05:00 Piyush Gupta editor@ijmbs.info Manish Porwal editor@ijmbs.info <p><strong>Background and Objective:</strong> We compared trans-right atrial (t-RA) versus combined (trans-right-atrial and trans-ventricular (t-RA/RV) approaches for intra-cardiac repair of Tetralogy of Fallot (TOF) for the pre-operative and post-operative right ventricular (RV) function. The RV function was calculated using a tricuspid annular plane systolic excursion (TAPSE) using two-dimensional (2-D) echocardiography.</p> <p><strong>Materials and Methods:</strong> This was a retrospective study. Fifty-three patients operated for the intra-cardiac repair of TOF between August 2019 and March 2021 were included in the study and divided into two groups based on the approach for repair as follows: t-RA or combined (t-RA/RV) approach. The first group (t-RA) had twenty-one patients, and the second group (combined t-RA/RV approach) had thirty-two patients. The assessment of pre-operative and post-operative RV function was done using TAPSE. Records of follow-up at 1 month and 3 months were evaluated.</p> <p><strong>Results:</strong> Age, body surface area (BSA), preoperative saturation, cardiopulmonary bypass time, aortic cross?clamp time, postoperative intensive care unit (ICU) stay, and hospital stay</p> <p>were similar in both groups. However, t?RA/RV group had more pleural effusions (9 vs. 1 patients, <em>P </em>&lt; 0.05), but had more improvements in Right Ventricular outflow tract (RVOT) gradients. There were no differences in arrhythmias in either group. Pre-operative TAPSE for both groups was similar (1.46 ± 0.27 vs. 1.61 ± 0.31, <em>P </em>&gt; 0.05) and so was the post?operative TAPSE at discharge (1.54 ± 0.31 vs. 1.49 ± 0.33, <em>P </em>&gt; 0.05), at 1 months (1.64 ± 0.25 vs. 1.48 ± 0.32, <em>P </em>&gt; 0.05) and 3months (1.75 ± 0.19 vs. 1.7 ± 0.15, <em>P </em>&gt; 0.05).</p> <p><strong>Conclusion:</strong> Both approaches provide adequate palliation with effective improvements in RVOT gradients for patients with TOF. A limited right ventriculotomy does not adversely affect early RV function or increase the incidence of arrhythmias at the immediate post-operative period and early follow-up. More extensive studies with prospective randomized design and longer follow-ups are needed to address these issues further.</p> <p><strong>Keywords:</strong> Tetralogy of Fallot, transatrial approach, intracardiac repair.</p> 2022-01-02T00:00:00-05:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies