PATTERN OF MYOCARDIAL FIBROSIS IN ISCHEMIC AND NON ISCHEMIC CARDIOMYOPATHY

Abstract

Background: The cardiomyopathies are defined as “heterogenous group of diseases of the myocardium associated with mechanical or electrical dysfunction that usually (but not invariably) exhibit inappropriate ventricular hypertrophy or dilatation and are due to variety of causes that frequently are genetic.

Methods: The cross sectional hospital based study was conducted in the Department of Radiodiagnosis in patients with heart failure with LVEF (Left Ventricular Ejection Fraction) of <45% without RWM (Regional Wall Motion) abnormality on echocardiography evaluated in department of cardiology at IGMC, Shimla over a period of one year.

Demographics:

Demographics

Overall Group

Male

Female

Mean Age (year ) ± SD

53.86  ± 16.34

 54.45  ± 19.41

53.94  ± 16.36

Gender (n)

38

17 (44.73%)

21(55.26%)

Results: Myocardial fibrosis was seen in 4 (100%) patients of ischemic cardiomyopathy and 3 (18.75%) patients of non ischemic cardiomyopathy with significant P value of 0.01 and odd ratio of 1.67.  The subendocardial myocardial fibrosis was seen in 3 (75%) patients of ischemic cardiomyopathy while it was not seen in non ischemic cardiomyopathy with significant P value of < 0.01 and odd ratio of 3.59.

Conclusion: Cardiac MRI has important role in dilated cardiomyopathies for distinguishing ischemic and non ischemic types as well as in evaluation of various etiological types.

Keywords: MRI, Myocardial, Cardiomyopathies