TO ESTIMATE LIPID PROFILE IN PATIENTS WITH COPD

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) includes persistent bronchitis and emphysema, which is generally caused due to smoking of tobacco. (COPD) is an obstructive lung disorder characterized by airflow limitation that is progressive, associated with severe inflammatory response in the air passages and the lungs due to toxic particles. It interferes with normal breathing and is not fully reversible.

Objectives: 1. To estimate lipid profile (Total cholesterol (TCH), Triglycerides (TG), High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low-density lipoprotein (VLDL)) in patients with Chronic Obstructive Pulmonary. 2. To find correlation of these parameters with severity of disease.

Material and Method: The study was conducted in Department of Biochemistry in collaboration with Department of Respiratory Medicine at Jawaharlal Nehru Medical College and AVBRH, Sawangi (Meghe) Wardha, India. Thirty-two patients diagnosed with COPD were selected from OPD and ward of Respiratory Medicine and thirty-two age and sex matched controls were taken.

Result: The analysis of total cholesterol, triglycerides, HDL, LDL, VLDL in cases and controls. Result was statistically significant in between cases and controls of total cholesterol (p<0.001), HDL (p<0.001) and LDL (p<0.001), and statistically not significant in between cases and controls of triglycerides (p=0.6) and VLDL (p=0.98).

Conclusion: We conclude that smoking significantly affect lipid profile in COPD patients, as it increases LDL levels and decreases HDL levels. Hence all patients with COPD patients who are smoker’s needs to check their lipid profile. COPD is considered as systemic disease with various co morbidities, which may affect the lipid profile.

Keywords: Lipid profile, COPD, AAT, CVD, TNF-?, CRP and GOLD.