BACTERIOLOGICAL PROFILE OF URINARY ISOLATES AND ITS PATTERN OF ANTIBIOTIC SENSITIVITY TESTS IN A TERTIARY CARE HOSPITAL IN NAVIMUMBAI.

Abstract

Urinary tract infection is one of the most common human infections. Furthermore there is rise in the Resistance of causative pathogens against the commonly prescribed antibiotics. Present study was aimed at finding the prevalence of such uropathogens and their antibiogram. Among 1059 suspected urinary samples were processed in the Department of Microbiology, D Y Patil Hospital, Nerul.,Navi-Mumbai. 580 (54.78%) were found to be culture positive. The predominant pathogen was E.coli (37.79%), while Enterococcus (30.30%), Klebsiella spp. (13.55%), Pseudomonas spp. (7.13%), Enterobacter spp. (2.67%), Acinetobacter spp. (2.67%), Citrobacter spp. (1.96%), Proteus spp. (2.14%), Staphylococcus aureus (0.71%), Streptococcus spp. (0.89%), Providentia rettgeri (0.18%) were other uropathogens isolated in this study.

Of the isolated pathogens, 98.58% Gram negative organisms were sensitive only to Colistin and 95.28% to Imipenem except Pseudomonas species, Enterobacter species and Acinetobacter species. More than 95.28% Gram negative organisms showed resistance to Amoxycillin-clavulanic acid. The resistant pattern for other antibiotics was as follows, Ciprofloxacin (83.96% except for Klebsiella, Enterobacter, Citrobacter, Proteus and Pseudomonas aeruginosa), Cephalosporins (73.3% except for Klebsiella, Pseudomonas aeruginosa and Proteus vulgaris).

Amongst Gram positive isolates (Enterococcus faecalis & Staphylococcus aureus), 100% of the isolates showed sensitivity to Linezolid and Vancomycin. Staphylococcus aureus also showed 100% sensitivity to Imipenem. 100% of the Staphylococcus aureus showed resistance to Penicillin by 94.71%. Enterococcus faecalis showed resistance to Penicillin 98.82% and to Co-trimoxazole. Enterococcus showed more multidrug resistant pattern amongst Gram positive isolates.