TO ASSESS SUBCLINICAL RNFL THICKNESS LOSS IN THE FELLOW EYES OF PATIENTS OF DEMYELINATING DISEASES.

Abstract

An was Observational clinical study conducted on 30 patients who attended the OPD of upgraded department of Ophthalmology, Index Medical College Hospital & Research Centre, Indore. 60 eyes of 30 different patients of diagnosed cases of multiple sclerosis, neuromyelitis optica, and clinically isolated syndrome who had an H/O attack of Optic neuritis.

Result: The difference between overall RNFL thickness in affected eyes and Fellow eyes is statistically significant. Chi square value is - 14.16.P value- 0.006 (<0.05)

Severity of RNFL thickness loss in affected eyes of NMO (45.5µm; 83.34%) is more than MS (66.15µm; 65%). In CIS, RNFL thickness is highest (111.5µm)

Conclusion: Severity of RNFL thickness loss is associated with the severity of visual impairment. Hence, can predict the progression of visual impairment in demyelinating diseases. Hence, evaluating the axonal damage, severity of visual impairment by measuring RNFL thickness loss is extremely useful in assessing the progression of visual loss and progression of demyelinating diseases.

Keywords: RNFL, Eyes, Demyelinating & Subclinical.