TO ASSESS THE ADVERSE EFFECT PROFILE OF SECOND LINE DRUG IN TB PATIENTS

Abstract

Background: A retrospective and prospective study including LPA /AFB CULTURE proven cases of MDR TB. Data will be collected from the patient attending the OPD & IPD in the Dept. of Respiratory Medicine Index Medical College, Indore.

Result: Out of 226 patients, 183 patients continue on treatment and 8 patients get cure and 12 patients dead and 12 patients defaulted the treatment.

Out of 226 patients, the present study shows that Gastrointestinal side effects are the most common 42.5%. 12 patients have renal toxicity and 8 patients have Arthalgia and 6 patients have cutaneous reactions and 14 patients developed hepatitis and 7 patients have some psychiatric illenss and 7 patients developed hearing defect.

Conclusion: Overall, these findings emphasize the importance of continuing the systematic surveillance of M. tuberculosis isolates to monitor the trends of drug resistance in different patient categories as well as its association with  HIV across the country to timely modify and strengthen the national programs in order to prevent the emergence of MDR-TB strains and avert the threat of XDR-TB.

Keywords: Profile, second Line Drug & TB.