Comparison of Efficacy of Autologous Platelet Rich Plasma Dressing versus Conventional Dressing in Healing of Chronic Non-healing Ulcer - A Prospective, Randomised and Controlled Study

Abstract

Background: Long-term morbidity is linked to chronic non-healing ulcers, which frequently do not improve with traditional wound care. Growth factor-rich autologous platelet-rich plasma (PRP) has become a popular biological supplement to improve wound healing.

Aim: To evaluate the effectiveness of conventional and autologous platelet-rich plasma dressings for the treatment of persistent, non-healing ulcers.

Methods: Over the course of a year, this prospective, randomized, controlled trial was carried out at IGIMS, Patna. PRP dressing (Group P, n = 60) and conventional dressing (Group C, n = 60) were randomly assigned to 120 patients with chronic non-healing ulcers. While traditional dressings were used every two days, PRP was created using a double-spin centrifugation method and applied once a week. For 20 weeks, patients were monitored. Rate of healing, ulcer size decrease, granulation tissue creation, epithelialization, necessity for surgery, and complications were among the outcomes evaluated.
Results: Compared to the standard dressing group, the PRP group showed considerably faster wound healing, higher reduction in ulcer size, earlier granulation tissue development, and earlier epithelialization (p<0.05). The PRP group required less surgical intervention and had a much shorter mean healing time. There were no significant negative effects noted.
Conclusion: Autologous PRP dressing is a safe and effective modality that significantly improves healing outcomes in chronic non-healing ulcers.

Keywords: Platelet-rich plasma; Chronic non-healing ulcer; Wound healing; Conventional dressing; Randomized controlled study