Association Between Hemorheological Alterations and High-Sensitivity Cardiac Troponin T Levels in Patients with Type 2 Diabetes Mellitus

Abstract

Background: Type 2 diabetes mellitus (T2DM) is associated with a significantly increased risk of cardiovascular morbidity and mortality. Subclinical myocardial injury may occur early in the disease course, even in the absence of overt coronary artery disease. High-sensitivity cardiac troponin T (hs-cTnT) has emerged as a sensitive biomarker for detecting low-grade myocardial injury. Hemorheological abnormalities, including altered blood viscosity and impaired microcirculatory flow, are increasingly recognized as contributors to diabetic cardiovascular complications.

Objective: To evaluate the association between hemorheological parameters and hs-cTnT levels in patients with T2DM using a microchannel array flow analyzer.

Methods: This cross-sectional research study included adult patients with T2DM. Hemorheological properties were assessed using a microchannel array flow analyzer, and hs-cTnT levels were measured using a high-sensitivity immunoassay. Associations between hemorheological variables and hs-cTnT concentrations were analyzed.

Conclusion: Hemorheological impairment is significantly associated with subclinical myocardial injury in patients with T2DM. Microchannel flow analysis may serve as a useful adjunctive tool for early cardiovascular risk stratification in diabetic patients.

Keywords: Type 2 diabetes mellitus, Hemorheology, High-sensitivity troponin T, Microcirculation, Cardiovascular risk