Study of Serum Lipoprotein (A) and Lipid Profile in Polycystic Ovarian Syndrome

Abstract

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age, often linked to metabolic disturbances, including dyslipidemia and increased cardiovascular risks. This study aims to assess serum lipoprotein (a) [Lp(a)] and lipid profiles in PCOS patients to establish potential cardiovascular risk factors. A case-control study was conducted on 100 women, 50 diagnosed with PCOS based on the Rotterdam criteria and 50 healthy controls. Serum Lp(a) and lipid profile, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), were measured. Results indicated significantly higher levels of Lp(a), TC, TG, and LDL in PCOS patients compared to controls, while HDL levels were significantly lower. These findings suggest that women with PCOS have a higher predisposition to cardiovascular diseases due to altered lipid metabolism. The study highlights the need for routine lipid monitoring and early interventions to mitigate cardiovascular risks in PCOS patients.

Keywords: Polycystic ovarian syndrome, lipoprotein (a), lipid profile, dyslipidemia, cardiovascular risk, metabolic disorder.