Comparison of two Different Doses of Dexmedetomidine in Attenuation of Haemodynamic Response During Endotracheal Extubation

Abstract

This study was a randomized, double-blinded, controlled trial that aimed to assess the effectiveness of two different dosages of dexmedetomidine (0.5 µg/kg and 1 µg/kg) in reducing the impact on blood pressure and heart rate during the removal of a breathing tube in 150 patients at AIIMS, Delhi. The findings demonstrated that the larger dosage effectively reduced the elevation in heart rate and blood pressure, minimised the occurrence of problems after extubation, and diminished the requirement for supplementary drugs in comparison to the lower dosage and placebo. The greater dosage also enhanced patient comfort scores but with a slightly higher occurrence of controllable bradycardia. These findings endorse the administration of a greater dosage of dexmedetomidine to enhance the clinical management of hemodynamic stability after extubation, specifically in patients with cardiovascular concerns.

Keywords: Dexmedetomidine, Endotracheal Extubation, Hemodynamic Responses, Patient Comfort.