MULTIDRUG RESISTANCE AMONG UROPATHOGENIC CLONAL GROUP A E. COLI ISOLATES: A COMPREHENSIVE STUDY

Abstract

Bacterial infections especially in women and the aged group are some of the most common infections in the world they include urinary tract infections. Of all the causative organisms in UTI, Escherichia coli species accounts for about 70-95% of the cases. This study aimed at understanding the extend and pattern of multidrug resistance (MDR) among uropathogenic Escherichia coli (UPEC) that are belonging to clonal group A, in order to identify key resistant genes and explain their distribution and effects towards treatment outcomes. The increasing prevalence of multidrug-resistant Escherichia coli (UPEC) strains especially those of clonal group A predispose UTI management to a lot of challenges. They found that the rate of MDR in clonal group A isolates was very high, with overall resistance to at least three antimicrobial classes noted in 80 percent of isolates. This present work also focuses on the high level of antibiotic resistance in clonal group A E. coli isolates. The high level of resistance to important antibiotic classes, coupled with the description of important resistance, suggest that approaching UTIs by MDR UPECs that are emerging is a complicate affair.

Keywords: multidrug resistance, urinary tract infections, Escherichia coli, Bacterial infections, uropathogenic Escherichia coli