Review on Gastroprotective Effect of Herbal Medicines

Abstract

Herbal medicines are very important to cure the various ailments of human. Demands of the herbal

medicines are increasing in both developed and under developed countries due to growing recognition of natural plants being lesser of side effect, easily available in surrounding place with low coast. Despite extensive research, the etiology ofpeptic ulcer disease remains unclear. Given the multiple processes that control acid and pepsin secretion and defense and repair of the gastroduodenal mucosa, it is likely that the cause of ulceration differs between individuals. Acid and pepsin appear to be necessary but not sufficient ingredients in the ulcerative process.. NSAIDs cause a significant number of gastric and duodenal ulcers; this is probably due to inhibition of prostaglandin production with loss of its protectiveeffects. In the absence of NSAIDs and gastrinoma, it appears that most gastric ulcers and all duodenal ulcers occur in the setting of H. pylori infection. Gastric ulcer often occurs with decreased acid-peptic activity, suggesting that mucosaldefensive impairments are more important. The combination of inflammation, protective deficiencies, and moderate amounts of acid and pepsin may be enough to induce ulceration. Many questions remain in understanding the pathophysiology of peptic ulcer disease. The physiology and pathophysiology of mucosal regeneration and the mechanisms by which H. pylori and inflammation disrupt normal gastroduodenal function will be fruitful areas of future investigation. In this review attempts have been made to know the antiulcer drug of natural origin with their suggestedmedicinal part.

Key Words: Peptic ulcer , H.pylori , Herbal Medicines ,NSAID’s