Outcome of Mifepristone and Misoprostol Verses Misoprostol for Induction of Labour in third Trimester Intra Uterine Foetal Death in Tertiary Care Center in P.B.M Hospital, Bikaner

Abstract

Background: Due to limited study was conducted in our hospital. The present study is undertaken to compare the effectiveness and safety of combination regime of mifeprostone and misoprostol with misoprostol alone in 28 week of IUD.

Methods: Hospital based prospective study conducted on 100 women. Group A (50 pregnant women with IUFD receiving combination of mifepristone and misoprostol) and Group B (50 pregnant women with IUFD receiving misoprostol alone group).

Results: The general characteristics of both groups comparable.  Mean Bishop score in group A and group B was 1.56 and 2.41 respectively. The mean induction delivery interval was more in group B than group A(25.98 hour versus 18.74 hour). In group A number of cases delivered within 24 hours of induction were more than group B. Mean number of 50µg misoprostol required in group A was 2.40±1.37 while in group B it was 2.54±1.30. Need of supplementation with oxytocin was more in group B as compared to group A. Mean birth weight in group A was 2.46±0.89 kg and in group II was 2.65±0.89kg. The induction was successful in 100.00% cases in group-A while in group-B was in 96.00%. In group-A, 94.00% cases had not found any complication, fever was found in 4.00% cases, retained placenta was found 2.00% cases. In group B, 78.00% cases were no found any complication, fever and nausea /vomiting, retained placenta was found in 6.00% cases each, uterine tachystole & PPH was found in 4.00% cases each.

Conclusion:  We concluded that both the regimen was equally safe, easy to administer and affordable but the Combination Regimen had a slight edge over misoprostol alone regimen in terms of tolerance, fewer side effects and efficacy with regard to early onset of labour, shorter Induction to Delivery Interval and relatively less dose of misoprostol than misoprostol alone regimen.

Keywords: Misoprostol, Mifeprostone, Labour, IUD