Study of Minerals and Trace Elements in Hypothyroidism Patients

Abstract

Background: Thyroid hormones, by their direct action on bone turnover, play a significant role in calcium and phosphorus homeostasis. This study was important because thyroid hormones play a role in calcium and phosphorous metabolism, which is often disrupted in thyroid dysfunction. In thyroid disease, it's important to keep an eye on increases in serum calcium and phosphorus levels. The aim of this study is to compare the levels of serum calcium and phosphorus in hypothyroidism patients to those in apparently safe controls. Iodine, selenium, copper, zinc, and other trace minerals can interfere with the correct production and metabolism of thyroid hormones.

Aim: Study of Minerals and Trace Elements in Hypothyroidism Patients.

Material and Method: Between February 2020 and March 2021, a clinical-based case control study was performed. A research group of 100 hypothyroid patients from the JLN Medical College and Hospital in Ajmer, Rajasthan was compared to a control group of 100 seemingly healthy people. Blood samples were taken from the classes, and serum calcium, phosphorus, magnesium, Copper (Cu), Zinc (Zn) and Selenium (Se) levels were estimated.

Results: The findings indicate a significant decrease in mean serum calcium levels in the test group compared to the control group and a significant increase in mean serum phosphorus levels in the test group compared to the control group in this sample. When compared to controls, serum magnesium levels were significantly higher with mean values.

Conclusion: In hypothyroid disorders, serum calcium and phosphorus levels are substantially altered. The levels of these minerals should be tested in hypothyroidism patients. The trace elements played a part in several metabolic processes as either necessary nutrients or as cofactors for various enzymes, which either directly or indirectly caused hypothyroidism. As a consequence, the findings of this study indicate that selenium, manganese, and zinc metabolism in hypothyroidism condition is aberrant.

Keywords: Thyroid stimulating hormone, Calcium, Phosphorus, Magnesium and Trace elements