FLUOROQUINOLONES: A BYGONE ERA? ANTIBIOGRAM OF VARIOUS BACTERIAL INFECTIONS IN A TERTIARY CARE HOSPITAL IN MALWA, CENTRAL INDIA

Abstract

Background: Ready availability of antibiotics over the counter poses a significant challenge to the Indian physicians. In our research paper we have compiled the data from various samples, grouped them according to sites and the bugs

Objective: To find out the commonest bug affecting the site of infection and the sensitivity pattern of the microbes to commonly used “empiric” antibiotics

Methods: Samples were collected from inpatients of Index medical hospital at the time of admission, if referred from other primary health care or after 3days of empirical therapy for all critical ill patients. Then grouped according to specimen sites like urine, pus, stool, blood, miscellaneous and further subgrouped according to the organisms found in these samples after culture.

Result: Total 500 samples were sent of which 242 positive samples were included in the study rest were either as no organisms grown or sensitive to other group of antibiotics. The Gram negatives were predominant (62%). Majority of the isolates were from urine, pus, blood and sputum accounting for 106, 74, 31 and 31 samples respectively. In urine isolates, major organism was E.coli with 24% sensitivity to fluoroquinolones. Klebsiella pneumoniae was the predominant isolate in pus and sputum samples with 35% and 9% sensitivity to fluoroquinolones respectively. In blood samples, major organism isolated was coagulase negative staphylococcus with 27% sensitivity to fluoroquinolones.

Conclusion: The present study revealed an alarming situation that we are losing a broad spectrum antibiotic like flouroquinolone, and emphasizes the need for regular monitoring of antibiotic resistance pattern among the bacterial isolates obtained from various infections in patients awailing our facility.