COMPARATIVE STUDY OF AST: ALT RATIO IN LIVER DISEASES IN A TERTIARY CARE HOSPITAL IN BAREILLY
DOI:
https://doi.org/10.32553/ijmbs.v3i5.247Keywords:
AST, ALT ratio, De Ritis ratio, Alcoholic Hepatitis, Viral Hepatitis, Obstructive Jaundice and Chronic HepatitisAbstract
Background: Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT), the enzymes predominantly found in the hepatocytes, exhibit specific elevations in serum levels in different liver diseases. The ratios of their serum levels (AST: ALT ratio or De Ritis ratio) also exhibit specific patterns providing important diagnostic clues. The objective of the study is to establish the diagnostic utility of the AST: ALT ratio in liver diseases.
Material and methods: The present study was conducted to measure the serum levels of these enzymes from the blood samples collected from a total of 60 patients with diagnosis of Alcoholic Hepatitis (AH, n= 18), Viral Hepatitis (VH, n= 18), Obstructive Jaundice (OJ, n= 06) and Chronic Hepatitis (CH, n= 18) to calculate their ratio as Mean ± SD, separately in each disease group. 24 normal healthy individuals were studied as control group. The data was analyzed using SPSS (Version 17.0) software and ‘p’ values were elicited using student-‘t’ test.
Results: An AST: ALT ratio of 2.005±0.833, 0.648±0.228, 0.865±0.147 and 1.314±0.305 was observed in AH, VH, OJ and CH respectively. Control group showed a mean AST: ALT ratio of 1.001±0.158. A significant difference (p<0.05) was observed when each case group was compared with control except OJ vs Control where the ‘p’ value was observed >0.05. A significant difference (p<0.05) was observed when comparison was done between any two of the disease groups.
Conclusion: AST: ALT ratio can be useful in differentiating the liver diseases.
Key words: AST:ALT ratio, De Ritis ratio, Alcoholic Hepatitis, Viral Hepatitis, Obstructive Jaundice and Chronic Hepatitis.
