COMPUTATIONAL REPURPOSED LIGANDS: POTENTIAL CURE FOR BLACK FUNGUS

Abstract

A rare but serious fungal infection, known as mucormycosis and colloquially as “ Black fungus”, is being detected relatively frequently among Covid 19 patients in some states of India. The disease often manifests in the skin and also affects the lungs and the brain.  With no prompt medicines accessible the scourge brought about by the disease is expanding step by step. A ton of researchers are continuing for the potential medication up-and-comer that could help the medical care framework in this battle. We present a docking?based screening using a quantum mechanical scoring of a library built from approved drugs and compounds that Cefuroxime, Amoxicillin, Peramivir, Fluconazole, Itraconazol, Micafungin,Quercetin, Carvacrol, Xanthones,Curcumin,Thymol and Resveratrol with Proteins with PDB id  6VCT could display antibacterial  activity against Black fungus. Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the disease. We hope that these findings may contribute to the rational drug design against Black fungus.