A PROSPECTIVE STUDY TO EVALUATE THE ROLE OF URIC ACID FOR PROGRESSION TO PREECLAMPSIA IN GESTATIONAL HYPERTENSIVE PREGNANCIES IN THE DEPARTMENT OF OBSTRETICS AND GYNECOLOGY, SMS MEDICAL COLLEGE

Abstract

Background: The purpose of this study was to study the role of serum uric acid level in progression to preeclampsia in gestational hypertensive pregnancies.

Methods: Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur.

Results: Uric acid level was significantly higher in with PIH (6.68±0.36 mg/dl) as compared to without PIH (4.92±0.57 mg/dl). Receiver-operator characteristic curve showed relatively poor sensitivity and specificity performance (area under the curve= 1.00) of serum uric acid level at the initial presentation of gestational hypertension for predicting the progression to preeclampsia The best cut-off revealed from the curve was 6.18 mg/dl.

Conclusion: In conclusion, higher serum uric acid levels at the initial presentation of gestational hypertension may indicate heightened risk of progression to preeclampsia and development of adverse maternal/ infant conditions.

Keywords: Eclampsia, Uric acid, Hypertension