THE RELATIONSHIP BETWEEN LEPTIN and ANTHROPOMETRIC PARAMETERS IN TYPE-2 DIABETIC PATIENTS

Abstract

Aim: The Relationship between Leptin & Antithropometric Parameters in Type-2 Diabetic Patients.

Methods: In the present study, adult’s (male & female) subjects were selected from the Diabetes Center at the medical college, India. Ethical approval was obtained from the local institution's review committee and consent was obtained from all participants. For the purposes of this study, subje

cts were classified into categories of abnormal glucose homeostasis if they had a single abnormal FPG. Anthropometric parameters of the subjects i.e. Blood pressure was measured using a mercury sphygmomanometer to the right arm while the individuals were in a sitting position. Blood samples were collected after a 12-hour fast for the determination of glucose, insulin, total cholesterol, HDL, triglycerides and leptin.

Results: A total of 140 diabetic patients suffering from metabolic syndrome were enrolled in the study. There were 90 male and 50 female patients of 60-70 years age group. The anthropometric parameters in both male and female subjects suffering from metabolic syndrome were studied. In the diabetes group, FPG and LDL were significantly higher than in the control. Total cholesterol was also significantly higher in women with diabetes.

Conclusion: In the above study, it was observed that serum leptin levels were significantly associated in females as compared to males with the metabolic syndrome. It is directly related with the serum insulin and lipid profile levels. The significant correlation of leptin to selected anthropometric measurements of obesity is confirmed in non-diabetic Subjects.  

Keywords: Leptin, Antithropometric Parameters, Diabetic Patients, Biochemical Parameters, Cholesterol, HDL & LDL