A COMPARATIVE STUDY OF KETOFOL (KETAMINE AND PROPOFOL) WITH PROPOFOL ALONE TO SEE EFFECT ON PULSE RATE DURING INDUCTION AND MAINTENANCE PHASE OF ANAESTHESIA IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY

Authors

  • Priyanka Thakur MD, Department of Anaesthesia, Indira Gandhi Medical College, Shimla, H.P., India
  • Prteet Negi MS, Department of General Surgery, Dr. Rajender Prasad Medical College Kangra, Tanda H.P., India
  • . Ajay Sood MD, Department of Anaesthesia, Indira Gandhi Medical College, Shimla, H.P., India
  • Aparna Sharma MD, Department of Anaesthesia, Indira Gandhi Medical College, Shimla, H.P., India

DOI:

https://doi.org/10.32553/ijmbs.v5i6.1971

Keywords:

Pulse rate, Propofol, Ketamine

Abstract

Background: In this study, we aimed to evaluate the intra and post-operative pulse rate of ketamine-propofol mixture (Ketofol) infusion in comparison with propofol infusion.

Methods: Prospective, randomized, double blinded controlled trial. After approval by the research ethics committee and written informed valid consent of the patients, the proposed study was carried out for a period of one year in 60 patients, in ASA-I and ASA-II patients, aged between 19 to 60 years of either sex, who were  posted for laparoscopic cholecystectomy surgery at Indira Gandhi Medical College, Shimla.

Results: HR for group K was significantly increased during intubation(89.30 ± 13.22) , 1 minute after intubation(91.30 ± 14.28), at 5minute (88.73 ± 11.94) and 10  minute(89.17 ± 12.53) in intraoperative period, every 5 minute before extubation(89.77 ± 12.82,89.93 ± 12.50, 90.13 ± 12.42),during extubation(92.10 ± 10.88) and at first 30 minutes in post operative period(88.17 ± 8.76) as compared to baseline HR(82.80 ± 10.95).HR in group P was significantly increased at 1 min after intubation(81.93 ± 10.77) , during extubation (85.80 ± 11.24) and initial 30 minute of postoperative period (82.80 ± 10.56) as compared to baseline HR(76.80 ± 12.55).

Conclusion: HR parameter was significantly on higher side in group K during intubation, one -five -10 minutes after intubation , at 15 minutes before extubation , during extubation  and at first 30 minutes of postoperative period  as compared to group P where it significantly increased at one minute after intubation , during extubation and at initial 30 minutes of postoperative period when compared with their respective baselines

Keywords: Pulse rate, Propofol, Ketamine

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Published

2021-06-22

How to Cite

Thakur, P. ., Negi, P. ., Sood, . A. ., & Sharma, A. . (2021). A COMPARATIVE STUDY OF KETOFOL (KETAMINE AND PROPOFOL) WITH PROPOFOL ALONE TO SEE EFFECT ON PULSE RATE DURING INDUCTION AND MAINTENANCE PHASE OF ANAESTHESIA IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY. International Journal of Medical and Biomedical Studies, 5(6). https://doi.org/10.32553/ijmbs.v5i6.1971

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