EFFICACY OF COMBINATION OF AMLODIPINE (5MG) AND LOSARTAN (50MG) WITH AMLODIPINE (5MG) MONOTHERAPY IN HYPERTENSIVE PATIENTS.

Abstract

Objective: Hypertension is the major public health issues, which is the leading causes of mortality and morbidity worldwide. In Nepal the amlodipine and combination of Amlodipine and losartan are the most frequently prescribed antihypertensive drugs. This study was conducted to study antihypertensive effect of Amlodipine (5mg) alone and combination of Amlodipine (5mg) and Losartan (50mg) in hypertensive patients among the community of Bharatpur, chitwan

Method: A prospective study of Hypertensive patient having amlodipine and losartan in Bharatpur, Chitwan, was conducted from 25^th July to 10^th September 2019. A total of 120 samples were obtained using a random sampling technique.

Result: Of 120 patients 60 patient were administering amlodipine along the maximum number of patient was from the age group 50-60(31.67%). the awareness about medicine and disease were found to be 15 % and 56 % respectively. The average mean of blood pressure reduction found to be 60/28 mmHg by amlodipine + losartan while in monotherapy it was found to be 47/15mmHg.

Conclusion: This study concluded that the mean reduction of blood pressure by the combination therapy was higher than monotherapy hence the combination therapy is found to be more efficious for the reduction of Blood pressure than monotherapy along and the use of PPIs has been extended to other conditions not requiring acid anti secretory therapy.

Keywords: Hypertension, Amlodipine, Losartan