RELIABLE MARKER OF ATHEROGENICITY IN TYPE 2 DM – A COMPARATIVE STUDY ON GLYCOSYLATION GAP AND HAEMOGLOBIN GLYCATION INDEX.

Abstract

Background: To prevent acute and chronic complications, monitoring & controlling the level of diabetic indicators become an integral part of diabetic care. Factors that increase or decrease the intracellular glucose level relative to external plasma glucose levels causes the alteration in glycation, which leads to discordance between HbA1C and fructosamine. Aim of the study was to compare the Cardiovascular disease(CVD) risk prediction property of GG(Glycosylation gap) & HGI (Haemoglobin glycation index), 2 statistical measures to assess the disparity between actual HbA1C and the predicted value of HbA1C in Diabetes Mellitus(DM),by correlating them with predictor of atherogenicity and CVD– Atherogenic index of plasma(AIP).

Materials & Method: This Cross sectional study conducted on 142 type 2 DM patients .Blood samples collected to estimate FBS, HbA1c, Fructosamine , Triglyceride &HDL. GG & HGI calculated from predicted HbA1C from fructosamine and Predicted HbA1C from mean blood glucose respectively.

Results: AIP&HGI showed significant correlation compared to GG and AIP. Study concludes the usefulness of HGI in type 2 DM as a regular monitor for CVD risk prediction for improved healthcare.

Keywords: Haemoglobin glycation index ; Glycosylation gap ;Cardiovascular disease.