TO STUDY OF LDH LEVEL IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a progressive disease of the lungs characterized by structural changes such as emphysema, airflow limitation, dynamic hyperinflation, air trapping, and peribronchial fibrotic remodeling of the lungs with significant systemic inflammatory components, induced by chronic exposures to smoking and/or occupational or environmental sources.

Methods: It is a case control study of 100 subjects divided into two groups including 50 healthy controls and 50 cases of COPD. Patients with history of respiratory infection, pneumonia, coronary heart disease, heart failure, and neuromuscular disease, renal and hepatic dysfunction were excluded.

Results: The statistically significant increased value of serum lactate dehydrogenase in cases as compared to control group with p value<0.05.

Conclusion-Rise in serum LDH levels, though known to occur in many respiratory conditions, has not been studied in depth. Based on our study results, we have proved that patients with COPD have raised serum LDH levels.

Keywords: COPD, Lactate dehydrogenase, Smoking.