TO COMPARE THE EFFICACY OF MIDAZOLAM IN DOSE OF 0.5 MG/KG AND 0.75 MG/KG FOR SEDATION.

Abstract

Study was conducted on 60 patients of both sexes taken for various surgical procedures taking from 30 to 90 minutes at Gajra Raja Medical College, Gwalior.

We found that none of the children in the 0.75?mg/kg dose group cried compared with 4 children (20%) in the c group and one child (5%) in the 0. 5?mg/kg dose group. The percentage of children who appeared uncomfortable (study recorded that they were crying or complaining) were the highest in the control dose group (45%).  Only 25% of the children in the 0.5?mg/kg dose group and 10% of the children in the 0.75?mg/kg dose group appeared uncomfortable.  Thus more children were comfortable (study recorded they were sleepy or quite but awake) in the 0.75?mg/kg dose group (90%) compared with the 0. 5?mg/kg dose group (75%) and the control group (55%). This difference was statistically significant between the control group and the group that received the 0.75mg/kg dose.

The number of children who had desirable sedation was similar in the 0.75?mg/kg dose groups. Induction of general anaesthesia was poor for 25% the children in the group that received the 0.5?mg/kg dose.

Keywords: Efficacy, Midazolam, Sedation & Anaesthesia.